Peptides usually support the look of smoothness, firmness, or density. Acids are used for the appearance of exfoliation, tone, or clarity. Many routines use both, but not always in the same step.

Active typeBest forRoutine note
PeptidesSmooth, firm, repair, growLayer before moisturizer.
Azelaic acidBrighten, clarify, calmUse SPF in daytime routines.