Matrixyl and Argireline are often grouped together because both are peptides, but they are not interchangeable. Argireline is the better match for expression-line softening. Matrixyl 3000 is the better match for skin that wants visible firmness and support.

PeptideBest forFirst routine
ArgirelineMovement-related creasesMorning or night after cleansing
Matrixyl 3000Firmness and bounceDaily before moisturizer